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Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). From the decay which appears to follow first order kinetics a half-life of 9 min was found for the compartment viagra natural of autophagic vacuoles. The induction of this protein is correlated with an increased capacity for zinc-65 uptake into cultured RPE.

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